Gene dosage effects on transmission ratio distortion and fertility in mice that carry t haplotypes
نویسندگان
چکیده
منابع مشابه
Spam1-associated transmission ratio distortion in mice: Elucidating the mechanism
BACKGROUND While transmission ratio distortion, TRD, (a deviation from Mendelian ratio) is extensive in humans and well-documented in mice, the underlying mechanisms are unknown. Our earlier studies on carriers of spontaneous mutations of mouse Sperm Adhesion Molecule 1 (Spam1) suggested that TRD results from biochemically different sperm, due to a lack of transcript sharing through the interce...
متن کاملGenome scans for transmission ratio distortion regions in mice.
Transmission ratio distortion (TRD) is the departure from the expected genotypic frequencies under Mendelian inheritance. This departure can be due to multiple physiological mechanisms during gametogenesis, fertilization, fetal and embryonic development, and early neonatal life. Although a few TRD loci have been reported in mouse, inheritance patterns have never been evaluated for TRD. In this ...
متن کاملMaternal transmission, sex ratio distortion, and mitochondria.
In virtually all multicellular eukaryotes, mitochondria are transmitted exclusively through one parent, usually the mother. In this short review, we discuss some of the major consequences of uniparental transmission of mitochondria, including deleterious effects in males and selection for increased transmission through females. Many of these consequences, particularly sex ratio distortion, have...
متن کاملTransmission-ratio distortion in the Framingham Heart Study
Transmission-ratio distortion (TRD) is a phenomenon in which the segregation of alleles does not obey Mendel's laws. As a simple example, a recessive locus that results in fetal lethality will result in live-born individuals sharing more alleles at this locus than expected under Mendel's laws. This could result in apparent linkage of the phenotype of 'being alive' to such a chromosomal regions....
متن کاملThe Influence of Genetic Background and the Transmission Ratio Distortion in Mice Homologous Chromosome 27 on /!-haplotype
Transmission ratio distortion is a characteristic of complete t-haplotypes, such that heterozygous males preferentially transmit the t-haplotype bearing chromosome 17 to the majority of their progeny. At least two genes contained within the t-haplotype have been identified as being required for such high transmission ratios. In this study we examine the effects of the genetic background and the...
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ژورنال
عنوان ژورنال: Genetical Research
سال: 1989
ISSN: 0016-6723,1469-5073
DOI: 10.1017/s0016672300028688